A Kinase Duet Performance in the Asymmetric Division of Drosophila Neuroblasts
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چکیده
منابع مشابه
A Kinase Duet Performance in the Asymmetric Division of Drosophila Neuroblasts
The ability of progenitor stem cells to divide asymmetrically allows for the production of diverse daughter cell fates.[...].
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The Rockefeller University Press $30.00 J. Cell Biol. Vol. 188 No. 5 693–706 www.jcb.org/cgi/doi/10.1083/jcb.200905024 JCB 693 Correspondence to Cayetano Gonzalez: [email protected] Abbreviations used in this paper: Baz, Bazooka; Dlg, Discs large; GMC, ganglion mother cell; Insc, Inscuteable; MARCM, mosaic analysis with a repressible cell marker; Mira, Miranda; MTOC, microtubule-organiz...
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The mechanisms that maintain the orientation of cortical polarity and asymmetric division unchanged in consecutive mitoses in Drosophila melanogaster neuroblasts (NBs) are unknown. By studying the effect of transient microtubule depolymerization and centrosome mutant conditions, we have found that such orientation memory requires both the centrosome-organized interphase aster and centrosome-ind...
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Drosophila neuroblasts are stem cells that divide asymmetrically to produce another large neuroblast and a smaller ganglion mother cell (GMC). During neuroblast division, several cell fate determinants, such as Miranda, Prospero and Numb, are preferentially segregated into the GMC, ensuring its correct developmental fate. The accurate segregation of these determinants relies on proper orientati...
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ژورنال
عنوان ژورنال: Journal of Developmental Biology
سال: 2017
ISSN: 2221-3759
DOI: 10.3390/jdb5030007